W.H.O. classification

Grade	Performance Status
0	Able to carry out all normal activity without restriction.
1	Restricted in physically strenuous activity but ambulatory and able to carry out light work.
2	Ambulatory and capable of all self-care but unable to carry out any work; up and about more than 50% of waking hours.
3	Capable of only limited self-care; confined to bed or chair more than 50% of waking hours.
4	Completely disabled; cannot carry on any selfcare; totally confined to bed or chair.

W.H.O. grading for toxicity


	grade 0	grade 1	grade 2	grade 3	grade 4

Gastro-intestinal
Biliribun ASAT/ALAT Alkaline phosphat	<= 1.25 x N*	1.26-2.5 x N	2.6-5 x N	5.1-10 x N	> 10 x N

Oral	None	Soreness/ery- thema	Erythema, ulcers, can eat solids	Ulcers, req liquid diet only	Alimentation not possible

Nausea/Vomiting	None	Naussea	Transient vomiting	Vomiting req therapy	Intractable vomiting

Diarrhea	None	Transient <2 days	Tolerable > 2 days	Intolerable req. therapy	Hemorrhagic dehydration

Renal, bladder
BUN or blood urea Creatinine	<= 1.25 x N	1.26-2.5 x N	2.6 - 5 x N	5.1 -10 x N	> 10 x N

Cutaneous	None	Erythema	Dry desquam- ation, ves- iculation prunitus	Moist desquamation ulceration	Exfoliative dermatitis, necrosis req. surgery

Hair	None	Minimal Loss	Moderat, patchy alopecia	Complete alopecia but reversible	Non-reversible alopecia

Cardiac
Function	None	Asymptomatic but abnormal cardiac sign	Transient symptomatic dysfunction no therapy required	Symptomatic dysfunction responsive to therapy	Symptomatic dysfunction nonresponsive to therapy

Neurotoxicity
Peripheral	None	Paresthesias and/or decreases tendon reflex	Severe paraesthesias and/or mild weakness	Intolerable paresthesias and or marked motor loss	Paralysis

* N = Upper limit of normal