| |
SCORE 0 |
SCORE 1 |
SCORE 2 |
SCORE 3 |
PERFORMANCE SCORE:
KPS / ECOG / LPS |
Asymptomatic and fully active
(ECOG 0; KPS
or LPS 100%) |
Symptomatic, fully ambulatory, restricted only in physically strenuous activity
(ECOG 1, KPS or LPS 80-90%) |
Symptomatic, ambulatory, capable of selfcare, > 50% of waking hours out of bed
(ECOG 2, KPS or LPS 60-70%) |
Symptomatic, limited self-care, > 50% of waking hours in bed
(ECOG 3-4, KPS or LPS < 60%) |
SKIN 1
Score % BSA
GVHD features to be scored by BSA:
- Maculopapular rash/erythema
- Lichen planus-like features
- Sclerotic features
- Papulosquamous lesions or ichthyosis>
- Keratosis pilaris-like GVHD
|
No BSA involved |
1-18% BSA |
19-50% BSA |
> 50% BSA |
| Skin features score |
No sclerotic features |
|
Superficial sclerotic features ‘not hidebound’ (able to pinch) |
One or more of the features:
– Deep sclerotoc features
– ‘Hidebound’ (unable to pinch)
– Impaired mobility
– Ulceration |
| MOUTH |
No symptoms |
Mild symptoms with disease signs but not limiting oral intake significantly |
Moderate symptoms with disease signs with partial limitation of oral intake |
Severe symptoms with disease signs on examination with major imitation of oral intake |
| EYES |
No symptoms |
Mild dry eye symptoms not affecting ADL (requirement of lubricant eyedrops ≤ 3 x per day) |
Moderate dry eye symptoms partially affecting ADL (requiring lubricant ing eyedrops > 3 x per day or punctal plugs), WITHOUT new visionimpairment due to KCS |
Severe dry eye symptoms significantly affecting ADL (special eyeware to relieve pain) OR unable to work because of ocular symptoms OR loss of vision due to KCS |
| GI TRACT |
No symptoms |
Symptoms without significant weight loss (< 5%)2 |
Symptoms associated with mild to moderate weight loss (5- 15%) or moderate diarrhea without significant interference with daily living) |
Symptoms associated with significant weight loss > 15%, requires nutritional supplement for most calorie needs OR esophageal dilation OR severe diarrhea with significant interference with daily living |
| LIVER |
Normal total bilirubin and ALT or AP < 3 x ULN |
Normal total bilirubin with ALT ≥ 3-5 x ULN or AP ≥ 3 x ULN |
Elevated total bilirubin but ≤ 3 mg/dl (≤ 50 µmol/L) or ALT > 5 x ULN |
Elevated total bilirubin > 3 mg/dl (≥ 50 µmol/L) |
| LUNG score |
FEV1 ≥ 80% |
FEV1 60-79% |
FEV1 40-59% |
FEV1 ≤ 39% |
| JOINTS AND FASCIA |
No symptoms |
Mild tightness of arms or legs, normal or mild decreased range of motion (ROM) ANDnot affecting ADL |
Tightness of arms or legs
OR
joint contractures, erythema thought due to fasciitis, moderate decrease ROM AND mild to moderate limitation of ADL |
Contractures WITH significant decrease of ROM AND significant limitation of ADL (unable to tie shoes, button shirts, dress self etc.) |
| GENITAL TRACT |
No symptoms |
Mild signs4 and females with or without discomfort on gynecologic exam |
Moderate signs and may have symptoms with discomfort on gynecologic exam |
Severe signs with or without symptoms |
| OVERALL GVHD SEVERITY (Opinion of the evaluator) |
No GVHD |
Mild |
Moderate |
Severe |
