Type: | Studiedocumentatie |
Ziektebeelden: | Sikkelcelziekte |
Leeftijd: | ≥18 jr |
Fase: | N.v.t. |
Lijn: | N.v.t. |
Status: | Open |
Locatie: | Amsterdam UMC |
Volledige titel | The role of Red cell characteristics, Angiogenesis, Viscosity and Oxygenation in the pathophysiology of Sickle cell related retinopathy (RAVOS study) |
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Samenvatting met in- en exclusiecriteria |
This mono-center case-control study will be conducted in the Amsterdam UMC, location AMC. SCD patients will be selected out of the large cohort of 300 patients. Since patients with HbSS and HbSC genotypes often have different clinical manifestations regarding organ damage, both genotypes will be included in this study to compare them. For both genotypes, a control group consisting of patients with the same genotype but without SCR will be recruited (matched for age, genotype and gender) in order to test differences between these groups in red cell characteristics, angiogenesis markers, viscosity and retinal oxygenation parameters. In total, four patient groups with 20 patients per group will be selected.
In order to be eligible to participate in this study, a subject must meet all of the following criteria: |
Veiligheidsinformatie |
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Niet geregistreerde geneesmiddelen |
nvt |
Geregistreerde geneesmiddelen |
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NB |
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Principal investigator Amsterdam UMC | nvt |
Principal investigator elders | Prof. Dr. Bart Biemond |